Madeline Little loves science. Her beloved scientist grandfather recently passed away and she continues in his tradition of writing SOPs. To make things more interesting, it is time to start Middle School and her best friend is off to a different school. She has struggles navigating the new friendships as well as the death in the family. Meanwhile her older sister just wants to be a cheerleader and hang out with the soccer players. However, she has a bad case of blood-clotting disorder that messes everything up. There are plenty of struggles and a humorous story of a "painting".
One day, just about everything bad happens. When she finally thinks she is making friends, they discover bad things she had written about them. Her sister is rushed to an out of town hospital after her poor attempts to cope with the blood clotting disorder. And to top it off, she may have ruined an important enzyme in her dad's experiment. These all help her to do some soul searching and begin the path towards apology and forgiveness. The boy that likes her big sister is one of the first one that starts out by interacting with the "little sister." They learn to help others and eventually make headway into patching up the relationships.
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